Pike, Kurt G. : rechercher sur Z-Library

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1

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Pike, Kurt G., Malagu, Karine, Hummersone, Marc G., Menear, Keith A., Duggan, Heather M.E., Gomez, Sylvie, Martin, Niall M.B., Ruston, Linette, Pass, Sarah L., Pass, Martin

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2013

2

Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656

Waring, Michael J., Clarke, David S., Fenwick, Mark D., Godfrey, Linda, Groombridge, Sam D., Johnstone, Craig, McKerrecher, Darren, Pike, Kurt G., Rayner, John W., Robb, Graeme R., Wilson, Ingrid

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 253 KB

english, 2012

3

High-Purity Boron Nitride Nanotubes via High-Yield Hydrocarbon Solvent Processing

Amin, Mahmoud S., Atwater, Bennett, Pike, Robert D., Williamson, Kurt E., Kranbuehl, David E., Schniepp, Hannes C.

Journal:

Chemistry of Materials

Année:

2019

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2019

4

A Concise Total Synthesis of Deoxyschizandrin and Exploration of Its Antiproliferative Effects and those of Structurally Related Derivatives

Shaojun Zheng, Dr. Sarah J. Aves, Luca Laraia, Dr. Warren R. J. D. Galloway, Dr. Kurt G. Pike, Prof. Wenjun Wu, Dr. David R. Spring

Journal:

Chemistry - A European Journal

Année:

2012

Langue:

english

Fichier:

PDF, 500 KB

english, 2012

5

ChemInform Abstract: High Loading Polymer-Supported N-Methylmorpholine N-Oxide: A Practically Efficient and Readily Recyclable Promoter of the Pauson—Khand Reaction.

Dearg S. Brown, Elaine Campbell, William J. Kerr, David M. Lindsay, Angus J. Morrison, Kurt G. Pike, Stephen P. Watson

Journal:

Année:

2001

Fichier:

PDF, 31 KB

2001

6

ChemInform Abstract: Radical Cyclizations of Methylenecyclopropyl Azetidinones — Synthesis of Novel Tricyclic β-Lactams.

David J. Penfold, Kurt Pike, Anthony Genge, Mike Anson, John Kitteringham, Jeremy D. Kilburn

Journal:

Année:

2001

Fichier:

PDF, 40 KB

2001

7

ChemInform Abstract: Polymer-Supported N-Methylmorpholine N-Oxide as an Efficient and Readily Recyclable Co-oxidant in the TPAP Oxidation of Alcohols.

Dearg S. Brown, William J. Kerr, David M. Lindsay, Kurt G. Pike, Paul D. Ratcliffe

Journal:

Année:

2001

Fichier:

PDF, 30 KB

2001

8

Aminative Rearrangement of 2-Alkoxy-3,4-dihydro-2H-pyrans: A Novel Stereocontrolled Route to Substituted Pyrrolidines.

Alan Armstrong, Graham R. Cumming, Kurt Pike

Journal:

Année:

2004

Fichier:

PDF, 135 KB

2004

9

A Novel Series of p38 MAP Kinase Inhibitors for the Potential Treatment of Rheumatoid Arthritis.

Dearg S. Brown, Andrew J. Belfield, George R. Brown, Douglas Campbell, Alan Foubister, David J. Masters, Kurt G. Pike, Wendy L. Snelson, Stuart L. Wells

Journal:

Année:

2005

Fichier:

PDF, 13 KB

2005

10

ChemInform Abstract: Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Tandem Carbocupration and Organocuprate Oxidation.

Sarah J. Aves, Kurt G. Pike, David R. Spring

Journal:

Année:

2011

Fichier:

PDF, 28 KB

2011

11

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W.R. Caulkett, Craig S. Donald, Mark L. Fenwick, Emma Grange, Keith M. Johnson, Craig Johnstone, Clifford D. Jones, Kurt G. Pike, John W. Rayner, Rolf P. Wal

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 135 KB

english, 2006

12

Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life

Kurt G. Pike, Joanne V. Allen, Peter W.R. Caulkett, David S. Clarke, Craig S. Donald, Mark L. Fenwick, Keith M. Johnson, Craig Johnstone, Darren McKerrecher, John W. Rayner, Rolf P. Walker, Ingrid Wil

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 696 KB

english, 2011

13

Radical cyclisations of methylenecyclopropyl azetidinones—synthesis of novel tricyclic β-lactams

David J Penfold, Kurt Pike, Anthony Genge, Mike Anson, John Kitteringham, Jeremy D Kilburn

Journal:

Tetrahedron Letters

Année:

2000

Langue:

english

Fichier:

PDF, 105 KB

english, 2000

14

Radical cascade reactions of methylenecyclopropane derivatives - synthesis of cis-fused bicyclo-3.4.0-nonanes and bicyclo-4.4.0-decanes

Kurt G. Pike, Christine Destabel, Mike Anson, Jeremy D. Kilburn

Journal:

Tetrahedron Letters

Année:

1998

Langue:

english

Fichier:

PDF, 234 KB

english, 1998

15

A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis

Dearg S. Brown, Andrew J. Belfield, George R. Brown, Douglas Campbell, Alan Foubister, David J. Masters, Kurt G. Pike, Wendy L. Snelson, Stuart L. Wells

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 277 KB

english, 2004

16

ChemInform Abstract: Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation.

Sarah J. Aves, Kieron M. G. O'Connell, Kurt G. Pike, David R. Spring

Journal:

Année:

2012

Fichier:

PDF, 27 KB

2012

17

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases

Dearg S. Brown, John G. Cumming, Paul Bethel, Jonathan Finlayson, Stefan Gerhardt, Ian Nash, Richard A. Pauptit, Kurt G. Pike, Alan Reid, Wendy Snelson, Steve Swallow, Caroline Thompson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 864 KB

english, 2012

18

ChemInform Abstract: Synthesis of 3-Substituted 2-Aminopyridines via Displacement of 3-Fluoro-2-nitropyridine.

Culshaw, Janet D., Eden, Jonathan M., Ford, Susannah J., Hayter, Barry, Perkins, David R., Pike, Kurt G.

Journal:

Année:

2012

Fichier:

PDF, 38 KB

2012

19

Expedient synthesis of biologically important sulfonylmethyl pyrimidines

Blades, Kevin, Demeritt, Julie, Fillery, Shaun, Foote, Kevin M., Greenwood, Ryan, Gregson, Clare, Hassall, Lorraine A., McGuire, Thomas M., Pike, Kurt G., Williams, Emma

Journal:

Tetrahedron Letters

Année:

2014

Langue:

english

Fichier:

PDF, 331 KB

english, 2014

20

Aminative rearrangement of 2-alkoxy-3,4-dihydro-2H-pyrans: a novel stereocontrolled route to substituted pyrrolidinesElectronic supplementary information (ESI) available: experimental details and characterisation data for all new compounds. See http://www.rsc.org/suppdata/cc/b3/b316554j/

Armstrong, Alan, Cumming, Graham R., Pike, Kurt

Journal:

Chemical Communications

Année:

2004

Langue:

english

Fichier:

PDF, 103 KB

english, 2004

21

Overcoming retinoic acid receptor-α based testicular toxicity in the optimisation of glucokinase activators

Waring, Michael J., Brogan, Iain J., Coghlan, Matthew, Johnstone, Craig, Jones, Huw B., Leighton, Brendan, McKerrecher, Darren, Pike, Kurt G., Robb, Graeme R.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 257 KB

english, 2011

22

Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2

Pike, Kurt G., Morris, Jeff, Ruston, Linette, Pass, Sarah L., Greenwood, Ryan, Williams, Emma J., Demeritt, Julie, Culshaw, Janet D., Gill, Kristy, Pass, Martin, Finlay, M. Raymond V., Good, Catherine

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 2.75 MB

english, 2015

23

A Proposed Battery of Childhood Tests for Discriminating between Different Levels of Intactness of Function in Elderly Subjects

Pelz, Kurt, Pike, Frances, Ames, Louise B.

Journal:

The Journal of Genetic Psychology

Année:

1962

Langue:

english

Fichier:

PDF, 851 KB

english, 1962

24

SPIE Proceedings [SPIE Substance Identification Technologies - Innsbruck, Austria (Sunday 3 October 1993)] Substance Identification Analytics - Recurrent back-propagation and Newton algorithms for training recurrent neural networks

Kuan, Chung-Ming, Hornik, Kurt, Liu, Tung, Flanagan, James L., Mammone, Richard J., Brandenstein, Albert E., Pike, Edward R., Thomopoulos, Stelios C. A., Boyer, Marie-Paule, Huang, H. K., Ratib, Osman

Année:

1994

Langue:

english

Fichier:

PDF, 319 KB

english, 1994

25

Matrix-based multiparameter optimisation of glucokinase activators: the discovery of AZD1092

Waring, Michael J., Johnstone, Craig, McKerrecher, Darren, Pike, Kurt G., Robb, Graeme

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 274 KB

english, 2011

26

Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Organocuprate Oxidation

Aves, Sarah., O’Connell, Kieron, Pike, Kurt, Spring, David

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 80 KB

english, 2012

27

Synthesis of 3-Substituted 2-Aminopyridines via Displacement of 3-Fluoro-2-nitropyridine

Culshaw, Janet, Eden, Jonathan, Ford, Susannah, Hayter, Barry, Perkins, David, Pike, Kurt

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 227 KB

english, 2012

28

Polymer-Supported N-Methylmorpholine N-Oxide as an Efficient and Readily Recyclable Co-oxidant in the TPAP Oxidation of Alcohols

Brown, Dearg S., Kerr, William J., Lindsay, David M., Pike, Kurt G., Ratcliffe, Paul D.

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 82 KB

english, 2001

29

Synthesis of Highly Substituted Symmetrical 1,3-Dienes via Tandem Carbocupration and Organocuprate Oxidation

Aves, Sarah, Pike, Kurt, Spring, David

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 99 KB

english, 2010

30

MEASUREMENT OF PSYCHOLOGIC FUNCTION IN GERIATRIC PATIENTS

PELZ, KURT S., AMES, LOUISE B., PIKE, FRANCES

Journal:

Journal of the American Geriatrics Society

Année:

1961

Langue:

english

Fichier:

PDF, 853 KB

english, 1961

31

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the Heat Shock Factor 1 (HSF1) stress pathway and CDK9.

Rye, Carl, Chessum, Nicola, Lamont, Scott, Pike, Kurt Gordon, Faulder, Paul F., Demeritt, Julie, Kemmitt, Paul D, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew, Isaac, Rosie, Goodwin, Louise, Boros

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.84 MB

english, 2016

32

ChemInform Abstract: Expedient Synthesis of Biologically Important Sulfonylmethyl Pyrimidines.

Blades, Kevin, Demeritt, Julie, Fillery, Shaun, Foote, Kevin M., Greenwood, Ryan, Gregson, Clare, Hassall, Lorraine A., McGuire, Thomas M., Pike, Kurt G., Williams, Emma

Journal:

Année:

2014

Fichier:

PDF, 29 KB

2014

33

Brachial and Cerebrovascular Functions Are Enhanced in Postmenopausal Women after Ingestion of Chocolate with a High Concentration of Cocoa

Marsh, Channa E, Carter, Howard H, Guelfi, Kym J, Smith, Kurt J, Pike, Kerryn E, Naylor, Louise H, Green, Daniel J

Journal:

Journal of Nutrition

Année:

2017

Langue:

english

Fichier:

PDF, 910 KB

english, 2017

34

Limbic and Basal Ganglia Neuroanatomical Correlates of Gait and Executive Function

McGough, Ellen L., Kelly, Valerie E., Weaver, Kurt E., Logsdon, Rebecca G., McCurry, Susan M., Pike, Kenneth C., Grabowski, Thomas J., Teri, Linda

Journal:

American Journal of Physical Medicine & Rehabilitation

Année:

2017

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2017

35

Correction: Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See DOI: 10.1039/c6md00159a

Rye, Carl S., Chessum, Nicola E. A., Lamont, Scott, Pike, Kurt G., Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D., Isaac, Rosie, Goodwin, Louise, Bo

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 121 KB

english, 2016

36

The Identification of Potent, Selective and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)

Pike, Kurt G., Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, DeAlmeida, Camila, Degorce, Sébastien L., Didelot, Myriam, Dishington, Allan, D

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2018

37

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Durant, Stephen T., Zheng, Li, Wang, Yingchun, Chen, Kan, Zhang, Lingli, Zhang, Tianwei, Yang, Zhenfan, Riches, Lucy, Trinidad, Antonio G., Fok, Jacqueline H. L., Hunt, Tom, Pike, Kurt G., Wilson, Joa

Journal:

Science Advances

Année:

2018

Langue:

english

Fichier:

PDF, 2.54 MB

english, 2018

38

Estimated annual and lifetime labor productivity in the United States, 2016: implications for economic evaluations

Grosse, Scott D., Krueger, Kurt V., Pike, Jamison

Journal:

Journal of Medical Economics

Année:

2018

Langue:

english

Fichier:

PDF, 974 KB

english, 2018